2.1.7 Developmental and Reproductive Toxicity

Ethylbenzene is not a teratogen or reproductive toxicant and is not (selectively) toxic to the developing fetus. In laboratory animals at doses that produced toxicity to the maternal animal (≥ 1000 ppm) as indicated by adverse clinical signs and reductions in body weight, ethyl benzene caused a delay in fetal development such as decreased body weights and increases in skeletal variations. No foetotoxicity was present in developmental toxicity studies at concentrations of 500 ppm or lower. Ethylbenzene, when administered at up to 500 ppm to rats, also did not adversely affect reproductive performance or offspring development over two generations. Furthermore, it has been shown that ethylbenzene is not (selectively) toxic to the developing nervous system.

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